Effects of Ticlopidine on Platelet Aggregation in Beagles with Unstable Angina

Aim To study the antiplatelet aggregation of ticlopidine (TC). Methods Using coronary artery Folts model in beagles, the efficacy of TC on platelet aggregation was studied. Results (1)TC16, 32 mg•kg -1 dramatically inhibited the frequency of CFRs dose-dependently, and the times of CFRs decreased by 27%, 56%, 95%, 100% respectively at 1-4 h than that in control group’s after TC 32 mg•kg -1 administration. CFRs were abolished and did not return when AD was infused after TC 32 mg•kg -1 administration. (2)The time for CFRs absolute disappearance of TC in dose of 32 mg•kg -1 was shorter than that in control group. (3)The platelet aggregation induced by ADP was inhibited obviously after TC 16,32 mg•kg -1 administration, and the aggregation in TC 32 mg•kg -1 didn’t return after AD administration. Conclusion TC had dose-dependent antiplatelet effects in beagles, suggesting TC has reliable therapeutical efficacy on angina pectoris.